Laboratory for Chronobiology and Aging (ChronAge) investigates circadian and homeostatic regulation of reproduction and physiological processes governed by reproductive hormones. Our research aim is to understand the temporal organization of processes that regulate the production of reproductive hormones during growth and aging of an individual, as well as the development of treatments that would eventually slow down the development of hypogonadism in aged individuals and the old phenotype of the organism.

Current research directions:

• Peripheral clock synchronization pathways in the reproductive axis;
• The effect of stress on the circadian system and the rhythm of endocrine gonadal function;
• Circadian clock and puberty: signalization that activates the reproductive axis;
• Signaling that contributes to the development of Leydig cells hypofunction in aged individuals;
• Low testosterone as a marker of aging: pharmacological manipulation of NO-cGMP signaling and slowing the development of hypogonadism in aged individuals.

 International projects

• “The CNG channels in Leydig cell – identification, characterization and functional coupling to testosterone production”; The project is financed by SANU and the Academy of Sciences of the Czech Republic; Project number: BH-2014; Project duration: 01.01. 2015 – 31.12.2020; Project manager: Prof. Dr. Silvana Andrić (Serbia).
• “MitoEAGLE-Mitochondrial mapping: Evolution-Age-Gender-Lifestyle-Environment” (https://www.cost.eu/actions/CA15203/); The project is financed by the European Commissariat of the EU; Project number: CA15203; Project duration: 01.04.2017 – 31.03.2021
• “ERNEST-European Research Network on Signal Transduction” (https://www.cost.eu/actions/CA18133); The project is financed by the European Commissariat of the EU; Project number: CA18133; Project duration: 01.04.2019 – 31.03.2023

• A breeding ground for laboratory animals (rats and mice) with a room for examining the influence of various factors from the external environment on the rhythmic activity of the animal.
• Systems for the detection of voluntary activity of laboratory rats at given time intervals.
• Equipment needed to work with primary and continuous cell lines.
• Equipment necessary for molecular biology methods for testing the expression and function of target proteins in the cell.

 International cooperation:

• Prof. Dr. Maria Dufau, Section of Molecular Endocrinology, National Institutes of Health and Child Development, National Institutes of Health (Bethesda, USA)
• Prof. Dr. Urs Albrecht, Department of Biology, University of Friborg (Switzerland)
• Prof. Dr. Mojca Narat, Faculty of Biotechnology, University of Ljubljana (Slovenia)
• Prof. Dr. Simon Horvat, Faculty of Biotechnology, University of Ljubljana (Slovenia)
• Prof. Dr. Damjana Rozman, Institute of Biochemistry, Faculty of Medicine, University of Ljubljana (Slovenia)
• Prof. Dr. Hana Zemkova, Laboratory for Cellular and Molecular Neuroendocrinology, Institute of Physiology, Czech Academy of Sciences (Prague, Czech Republic)

 Cooperation with institutions in Serbia:

• Prof. Dr. Dušan Lalošević, Faculty of Medicine, University of Novi Sad
• Ass. Prof. Dr. Ivan Čapo, Faculty of Medicine, University of Novi Sad
• Prof. Dr. Aleksandar Kupusinac, Faculty of Technical Sciences, University of Novi Sad